AF/LE Purified Anti-Mouse CD119 Monoclonal Antibody | DL21411F

AF/LE Purified Anti-Mouse CD119 Monoclonal Antibody | DL21411F | Gentaur UK, US & Europe Distribution

Host: Rat

Synonyms: Interferon gamma receptor 1, Ifngr1, IFN-gamma-R1, IFN-gamma-R-alpha, CD119

Reactivity: Mouse

Application: FCM

Background: CDw119 is a 90 kD immunoglobulin superfamily member, also known as IFN-γRα chain. It is a class II cytokine receptor family member that serves as a IFN-γ-binding chain associated with the IFN-γ β chain also known as AF-1. In addition to ligand binding, CDw119 participates in ligand trafficking. CDw119 is expressed on T and B cells, NK cells, fibroblasts, endothelial, and epithelial cells. Binding of IFN-γ induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. IFN-γ initiates and regulates a variety of immune responses.

Concentration: 0.2 mg/mL

Conjugation: None (Purified antibody, Azide Free/Low endotoxin)

Buffer: 0.2 μm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg ( < 0.002EU/μg) as Determined by LAL gel clotting assay.

Clone: GR-20

Isotype: Rat IgG2a, κ