AF/LE Purified Anti-Mouse CD8a Monoclonal Antibody | DL21247F

AF/LE Purified Anti-Mouse CD8a Monoclonal Antibody | DL21247F | Gentaur UK, US & Europe Distribution

Host: Rat

Synonyms: T-cell surface glycoprotein CD8 alpha chain, CD8A, T-lymphocyte differentiation antigen T8/Leu-2, MAL

Reactivity: Mouse

Application: Block, Depletion, FCM, WB, IF, IP

Background: CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α (CD8a) /β (CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

Concentration: 0.2 mg/mL

Conjugation: None (Purified antibody, Azide Free/Low endotoxin)

Buffer: 0.2 μm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg ( < 0.002EU/μg) as Determined by LAL gel clotting assay.

Clone: 53-6.7

Isotype: Rat IgG2a, κ