AF/LE Purified Anti-Mouse CD279/PD-1 Monoclonal Antibody | DL21637F

AF/LE Purified Anti-Mouse CD279/PD-1 Monoclonal Antibody | DL21637F | Gentaur UK, US & Europe Distribution

Host: Rat

Synonyms: PD-1, Programmed Death-1

Reactivity: Mouse

Application: Block, Neut, FCM, WB, IHC, IF

Background: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2) . It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

Concentration: 0.2 mg/mL

Conjugation: None (Purified antibody, Azide Free/Low endotoxin)

Buffer: 0.2 μm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg ( < 0.002EU/μg) as Determined by LAL gel clotting assay.

Clone: 29F.1A12

Isotype: Rat IgG2a, κ