AF/LE Purified Anti-Mouse CD366/Tim-3 Monoclonal Antibody | DL22112F

AF/LE Purified Anti-Mouse CD366/Tim-3 Monoclonal Antibody | DL22112F | Gentaur UK, US & Europe Distribution

Host: Rat

Synonyms: TIM3, TIMD3, HAVcr-2, TIMD-3

Reactivity: Mouse

Application: FCM, Block

Background: CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells) . Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

Concentration: 0.2 mg/mL

Conjugation: None (Purified antibody, Azide Free/Low endotoxin)

Buffer: 0.2 μm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg ( < 0.002EU/μg) as Determined by LAL gel clotting assay.

Clone: RMT3-23

Isotype: Rat IgG2a, κ