AF/LE Purified Anti-Mouse CD54 Antibody[YN1/1.7.4] | E-AB-F10180

AF/LE Purified Anti-Mouse CD54 Antibody[YN1/1.7.4] | E-AB-F10180 | Gentaur UK, US & Europe Distribution

Category: Flowcytometry Antibody

Synonyms: Intercellular adhesion molecule 1,Icam1,MALA-2,MyD10,CD54,Icam-1

Swissprot Code: P13597

Application: FCM,IF

Reactivity: Mouse

Host: Mouse

Isotype: Mouse IgG1, κ

Research Areas: Immunology,Microbiology,Signal Transduction,Kits/ Lysates/ Other

Backgroun: CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.

Concentration: 0.5 mg/mL

Storage: Store at 2~8°C. Do not freeze.

Immunogen: N/A

Buffer: 0.2 μm filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.

Purification Method: N/A

Dilution: N/A

Clone: YN1/1.7.4

Conjugation: None (Purified antibody-Azide Free/Low endotoxin)

Moleculair Weight(Calculated): N/A

Moleculair Weight(Observed): N/A