AF353 | B2318

A potent P2X3/P2X2/3 receptor antagonist; inhibits human and rat P2X3 (pIC₅₀ = 8.0).

AF-353 is a potent P2X3/P2X2/3 receptor antagonist; inhibits human and rat P2X3 (pIC₅₀ = 8.0).

B2318 | AF353 DataSheet

Alternate Name/Synonyms: Ro-4,5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 865305-30-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₄H₁₇IN₄O₂

Molecular Weight: 400.22

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: >30 mg/ml (DMSO) in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent P2X3/P2X2/3 receptor antagonist

MDL Number: N/A

PubChem CID: 15953802

SMILES: CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)I)OC

InChi: InChI=1S/C14H17IN4O2/c1-7(2)8-4-11(20-3)9(15)5-10(8)21-12-6-18-14(17)19-13(12)16/h4-7H,1-3H3,(H4,16,17,18,19)

InChi Key: AATPYXMXFBBKFO-UHFFFAOYSA-N