AF488 Anti-Human CD197/CCR7 Antibody[G043H7] | E-AB-F1159L

AF488 Anti-Human CD197/CCR7 Antibody[G043H7] | E-AB-F1159L | Gentaur UK, US & Europe Distribution

Category: Flowcytometry Antibody

Synonyms: CMKBR7, EBI1, EVI1,CCR-7,CDw197

Swissprot Code: P32248

Application: FCM

Reactivity: Human

Host: Mouse

Isotype: Mouse IgG1, κ

Research Areas: Cancer, Immunology, Signal transduction

Backgroun: CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Nave T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis. Product Details

Concentration: N/A

Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Immunogen: N/A

Buffer: PBS with 0.05% Proclin300, 1% BSA

Purification Method: N/A

Dilution: N/A

Clone: G043H7

Conjugation: AF488

Moleculair Weight(Calculated): N/A

Moleculair Weight(Observed): N/A