AF488 Anti-Human CD47 Antibody[CC2C6D4] | E-AB-F1060L

AF488 Anti-Human CD47 Antibody[CC2C6D4] | E-AB-F1060L | Gentaur UK, US & Europe Distribution

Category: Flowcytometry Antibody

Synonyms: Leukocyte surface antigen CD47,Cd47,Integrin-associated protein,IAP

Swissprot Code: Q08722

Application: FCM

Reactivity: Human

Host: Mouse

Isotype: Mouse IgG1, κ

Research Areas: Cancer, Immunology

Backgroun: CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. Two splice variants have been described in the cytoplasmic tail, the shorter form is expressed in bone-marrow-derived cells, endothelial cells, and fibroblasts while the longer form is expressed by neural tissues. CD47 expression is widely distributed in hematopoietic cells including thymocytes, T cells, B cells, monocytes, platelets, and erythrocytes as well as epithelial cells, endothelial cells, fibroblasts, and neural tissues. CD47 functions as an adhesion molecule and thrombospondin receptor and is non-covalently associated with β3 integrins CD51/CD61, CD41/CD61. Thrombospondin is a ligand for CD47; in the absence of CD47 mice show defects in host defense and β3 integrin-dependent ligand binding, migration, and cellular activation. CD47 is also part of the Rh complex on erythrocytes.

Concentration: N/A

Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Immunogen: N/A

Buffer: PBS with 0.05% Proclin300, 1% BSA

Purification Method: N/A

Dilution: N/A

Clone: CC2C6D4

Conjugation: AF488

Moleculair Weight(Calculated): N/A

Moleculair Weight(Observed): N/A