AF647 Anti-Mouse CD103 Antibody[M290] | E-AB-F1090UM

AF647 Anti-Mouse CD103 Antibody[M290] | E-AB-F1090UM | Gentaur UK, US & Europe Distribution

Category: Flowcytometry Antibody

Synonyms: Integrin alpha-E,Itgae,Integrin alpha M290,CD103

Swissprot Code: Q60677

Application: FCM

Reactivity: Mouse

Host: Rat

Isotype: Rat IgG2a, κ

Research Areas: Signal Transduction,Immunology,Stem Cells

Backgroun: CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

Concentration: 0.5 mg/mL

Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Immunogen: N/A

Buffer: PBS with 0.05% Proclin300, 1% BSA

Purification Method: N/A

Dilution: N/A

Clone: M290

Conjugation: AF647

Moleculair Weight(Calculated): N/A

Moleculair Weight(Observed): N/A