LBD
AFG3L2 Antibody (N-term) [APG01599G]
- SKU:
- LBD-APG01599G
- Availability:
- Usually ships in 5 working days
Description
AFG3L2 Antibody (N-term) [APG01599G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This AFG3L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-80 amino acids from the N-terminal region of human AFG3L2.
Cellular Localisation: Mitochondrion. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8JZQ2}; Multi-pass membrane protein
Molecular Weight: 88584
Clone: Polyclonal
Gene Name: AFG3L2 (HGNC:315)
Gene ID: 10939
Function: ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (PubMed:27642048) . Required for paraplegin (SPG7) maturation (PubMed:30252181) . After its cleavage by mitochondrial-processing peptidase (MPP), it converts paraplegin into a proteolytically active mature form (By similarity) . Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (PubMed:22354088, PubMed:30252181) . Involved in the regulation of OMA1-dependent processing of OPA1 (PubMed:32600459, PubMed:30252181) .
Summary: Tissue Location: Ubiquitous. Highly expressed in the cerebellar Purkinje cells.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P
Dilution: WB--1:1000 IHC-P--1:100~500
Synonyms: AFG3-like protein 2, 3424-, Paraplegin-like protein, AFG3L2