Afuresertib hydrochloride | B1848

Afuresertib is a potent and selective Akt inhibitor with potential antineoplastic activity. Afuresertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.

Afuresertib is a potent and selective Akt inhibitor with potential antineoplastic activity. Afuresertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.

B1848 | Afuresertib hydrochloride DataSheet

Alternate Name/Synonyms: N-​[(1S)​-​2-​amino-​1-​[(3-​fluorophenyl)​methyl]​ethyl]​-​5-​chloro-​4-​(4-​chloro-​1-​methyl-​1H-​pyrazol-​5-​yl)​-2-​thiophenecarboxamide, monohydrochloride​

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1047645-82-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₈H₁₇Cl₂FN₄OS • HCl

Molecular Weight: 463.8

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO >30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective Akt inhibitor

MDL Number: N/A

PubChem CID: 46843056

SMILES: CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl.Cl

InChi: InChI=1S/C18H17Cl2FN4OS.ClH/c1-25-16(14(19)9-23-25)13-7-15(27-17(13)20)18(26)24-12(8-22)6-10-3-2-4-11(21)5-10;/h2-5,7,9,12H,6,8,22H2,1H3,(H,24,26);1H/t12-;/m0./s1

InChi Key: YFQJOPFTGMHYNV-YDALLXLXSA-N