AG-120 (Ivosidenib) | B1163

AG-120 is a potent isocitrate dehydrogenase type 1 (IDH1) inhibitor, with potential antineoplastic activity. Upon oral administration it specifically inhibits a mutated form of IDH1 in the cytoplasm inhibiting the formation of oncometabolite, 2-hydroxyglutarate (2HG). This leads to induction of cellular differentiation and an inhibition of cellular proliferation

AG-120 is a potent isocitrate dehydrogenase type 1 (IDH1) inhibitor, with potential antineoplastic activity. Upon oral administration it specifically inhibits a mutated form of IDH1 in the cytoplasm inhibiting the formation of oncometabolite, 2-hydroxyglutarate (2HG). This leads to induction of cellular differentiation and an inhibition of cellular proliferation

B1163 | AG-120 (Ivosidenib) DataSheet

Alternate Name/Synonyms: (2S)-N-(1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

Appearance: White Solid

Formulation: N/A

CAS Number: 1448347-49-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₂₂ClF₃N₆O₆

Molecular Weight: 582.97

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>5 mg/ml))

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent isocitrate dehydrogenase type 1 (IDH1) inhibitor

MDL Number:

PubChem CID: 89699486

SMILES: C1CC(=O)N(C1C(=O)N(C2=CC(=CN=C2)F)C(C3=CC=CC=C3Cl)C(=O)NC4CC(C4)(F)F)C5=NC=CC(=C5)C#N

InChi: 1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25?/m0/s1

InChi Key: WIJZXSAJMHAVGX-XADRRFQNSA-N