AG 1478 | 1800

Cell-permeable. A potent EGFR Tyrosine Kinase (TK) inhibitor with an IC₅₀ of 3 nM. Only weakly inhibits PDGFR and HER2-NEU kinases (IC₅₀ >100 µM).

AG 1478 is a potent EGFR Tyrosine Kinase (TK) inhibitor with an IC₅₀ of 3 nM. Only weakly inhibits PDGFR and HER2-NEU kinases (IC₅₀ >100 µM).

1800 | AG 1478 DataSheet

Alternate Name/Synonyms: 4-(3’-Chloroanilino)-6,7-dimethoxyquinazoline; Tyrphostin AG 1478

Appearance: White solid

Formulation: N/A

CAS Number: 175178-82-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₄ClN₃O₂

Molecular Weight: 315.75

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO:Methanol 1:1 v/v (10 mg/ml), Ethanol (10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent EGFR Tyrosine Kinase (TK) inhibitor

MDL Number: MFCD00270914

PubChem CID: 53429216

SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)CC3=CC(=CC=C3)Cl)OC

InChi: InChI=1S/C17H15ClN2O2/c1-21-16-8-13-14(7-11-4-3-5-12(18)6-11)19-10-20-15(13)9-17(16)22-2/h3-6,8-10H,7H2,1-2H3

InChi Key: DOBKKEHYAFERJH-UHFFFAOYSA-N