AGK7 | B2843

AGK7 is an inactive control and an isomer of AGK2. AGK2 is a cell-permeable, selective inhibitor of SIRT2 which is a NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase (IC₅₀ = 3.5 µM). AGK2 rescues α-synuclein toxicity in α-Syn-H4 cells while AGK7 does not affect α-synuclein aggregation. AGK7 inhibits SIRT3 with an IC₅₀ value greater than 5 µM and inhibits SIRT1 and SIRT2 with an IC₅₀ greater than 50 µM.

AGK7 is an inactive control and an isomer of AGK2. AGK2 is a cell-permeable, selective inhibitor of SIRT2 which is a NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase (IC₅₀ = 3.5 µM). AGK2 rescues α-synuclein toxicity in α-Syn-H4 cells while AGK7 does not affect α-synuclein aggregation. AGK7 inhibits SIRT3 with an IC₅₀ value greater than 5 µM and inhibits SIRT1 and SIRT2 with an IC₅₀ greater than 50 µM.

B2843 | AGK7 DataSheet

Alternate Name/Synonyms: 2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-8-ylprop-2-enamide; SIRT2 Inhibitor (Inactive Control)

Appearance: A crystalline solid

Formulation:

CAS Number: 304896-21-7

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₂₃H₁₃Cl₂N₃O₂

Molecular Weight: 434.27

Cell-Permeable?: True

Purity: ≥95%

Solubilities: ~0.5 mg/ml in in DMSO, ~0.2 mg/ml in DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inactive control and isomer of AGK2 (SIRT2 inhibitor)

MDL Number:

PubChem CID: 1372572

SMILES: C1=CC2=C(C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N)N=CC=C2

InChi: InChI=1S/C23H13Cl2N3O2/c24-16-6-8-19(25)18(12-16)21-9-7-17(30-21)11-15(13-26)23(29)28-20-5-1-3-14-4-2-10-27-22(14)20/h1-12H,(H,28,29)/b15-11+

InChi Key: WRDKBSLEHFRKGG-RVDMUPIBSA-N