AGTPBP1 Antibody (N-term) [APR31557G]

AGTPBP1 Antibody (N-term) [APR31557G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This AGTPBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 363-392 amino acids from the N-terminal region of human AGTPBP1.

Cellular Localisation: Cytoplasm. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q641K1}. Nucleus Mitochondrion {ECO:0000250|UniProtKB:Q641K1}. Note=Localizes in both the cytoplasm and nuclei of interphase and dividing cells

Molecular Weight: 138448

Clone: Polyclonal

Gene Name: AGTPBP1 (HGNC:17258)

Gene ID: 23287

Function: Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed:22170066, PubMed:24022482, PubMed:30420557) . Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta- tubulin (PubMed:22170066, PubMed:24022482, PubMed:30420557) . Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:24022482) . Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK (PubMed:22170066) . Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Cytosolic carboxypeptidase 1, 3417-, ATP/GTP-binding protein 1, Nervous system nuclear protein induced by axotomy protein 1 homolog, AGTPBP1, CCP1, KIAA1035, NNA1