AICAR | 1687

A cell- permeable activator of AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle. AICAR is able to activate the molecular circuitry of pluripotency in mESC and to induce the expression of several key regulators of pluripotency in somatic cells.

AICAR is a cell- permeable activator of AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis.

1687 | AICAR DataSheet

Alternate Name/Synonyms: 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside; AICA-Riboside; NSC 105823

Appearance: Tan powder

Formulation: N/A

CAS Number: 2627-69-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₉H₁₄N₄O₅

Molecular Weight: 258.23

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: H₂O

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An AMPK activator

MDL Number: MFCD00869751

PubChem CID: 17513

SMILES: C1=NC(=C(N1C2C(C(C(O2)CO)O)O)N)C(=O)N

InChi: InChI=1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1

InChi Key: RTRQQBHATOEIAF-UUOKFMHZSA-N