AK2 polyclonal Antibody | BS6319

AK2 polyclonal Antibody | BS6319 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:2000 IHC: 1:50~1:200

Background: Adenylate kinases 1-5 (designated AK1-5) are a set of enzymes that regulate the phosphorylation state of intracellular adenine nucleotides, which are the principle high-energy phosphoryl-carrying molecules in living cells. AKs influence metabolic signals, which include gene expression, ion channel activity and protein kinase-mediated signaling, by catalyzing phosphoryl transfer between adenine nucleotides (AMP, ADP, ATP) . Inherited mutations leading to AK deficiencies in erythrocytes have been implicated in hemolytic anemia. AK2 is found in the mitochondria of liver and heart tissues and is the only AK that localizes to the mitochondrial intermembrane space. In apoptotic cells, AK2 is the only AK that translocates into the cytosol concomitantly with cytochrome c, suggesting that only intermembrane proteins are released from mitochondria during the early stages of apoptosis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: AK2 polyclonal Antibody detects endogenous levels of AK2 protein.

Molecular Weight: ~ 32 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Adenylate kinase 2, mitochondrial; AK 2; ATP-AMP transphosphorylase 2; ATP:AMP phosphotransferase; Adenylate monophosphate kinase; AK2; ADK2

Immunogen: Recombinant full length Human AK2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: