Akt Inhibitor (10-NCP) | 2338

Cell-permeable. A reversible and specific inhibitor of Akt activity in vitro (complete inhibition at < 5 µM). Displays minimal effect on PI 3-K, PDK1, or SGK1. Blocks IGF-I stimulated nuclear translocation of Akt in Rh1 cells and suppressed growth of Rh1, Rh18, and Rh30 cells (IC₅₀ = 2–5 µM). Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein.

Akt Inhibitor (10-NCP) is a reversible and specific inhibitor of Akt activity in vitro (complete inhibition at < 5 µM). Displays minimal effect on PI 3-K, PDK1, or SGK1.

2338 | Akt Inhibitor (10-NCP) DataSheet

Alternate Name/Synonyms: 10-(4′-(N-diethylamino)butyl)-2-chlorophenoxazine hydrochloride

Appearance: White solid

Formulation: N/A

CAS Number: 925681-41-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₅ClN₂O∙HCl

Molecular Weight: 381.34

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (60 mg/ml) or H2O (1 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A reversible and specific inhibitor of Akt activity in vitro

MDL Number: MFCD09038570

PubChem CID: 16760284

SMILES: CCN(CC)CCCCN(C(C=C(Cl)C=C1)=C1O2)C3=C2C=CC=C3.[H]Cl

InChi: InChI=1S/C20H25ClN2O.ClH/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23;/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3;1H

InChi Key: SVKSJUIYYCQZEC-UHFFFAOYSA-N