AKT1/2 (Phospho-T308/T309) polyclonal Antibody | BS64584

AKT1/2 (Phospho-T308/T309) polyclonal Antibody | BS64584 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: AKT, also known as protein kinase B (PKB), is a 57 kDa serine/threonine protein kinase. There are three mammalian isoforms of Akt: AKT1 (PKB alpha), AKT2 (PKB beta) and AKT3 (PKB gamma) with AKT2 and AKT3 being approximately 82% identical with the AKT1 isoform. Each isoform has a pleckstrin homology (PH) domain, a kinase domain and a carboxy terminal regulatory domain. AKT was originally cloned from the retrovirus AKT8, and is a key regulator of many signal transduction pathways. Its tight control over cell proliferation and cell viability are manifold; overexpression or inappropriate activation of AKT has been seen in many types of cancer.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: AKT1/2 (Phospho-T308/T309)  polyclonal Antibody detects endogenous levels of AKT1/2 protein only when phosphorylated at Thr308/Thr309.

Molecular Weight: ~ 55 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: AKT1; AKT1; AKT2; AKT3; MGC9965; Oncogene AKT1; PKB alpha; PKB; PKB beta; PKBalpha; PRKBA; PRKBB; PRKBG; Protein kinase B; Protein kinase B beta; Protein kinase B gamma; Proto-oncogene c-Akt; RAC alpha; RAC; RAC gamma; RAC PK alpha; RAC PK beta; RAC

Immunogen: Synthetic phosphopeptide derived from human AKT1/2 around the phosphorylation site of Threonine 308/Threonine 309.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Neuronal and Glial Cell Marker Atlas,Contribution of ECM and Cytoskeletal Factors to EMT,