Alendronate sodium | 2168

Alendronate sodium is a bisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption. It inhibits bone resorption in vitro with an IC₅₀ value of 2 nM. Also acts as a farnesyl diphosphate synthase inhibitor (IC₅₀ = 460 nM) and CD45 protein tyrosine phosphatase inhibitor.

Alendronate sodium is a bisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption. It inhibits bone resorption in vitro with an IC₅₀ value of 2 nM. Also acts as a farnesyl diphosphate synthase inhibitor (IC₅₀ = 460 nM) and CD45 protein tyrosine phosphatase inhibitor.

2168 | Alendronate sodium DataSheet

Alternate Name/Synonyms: Sodium [4-amino-1-hydroxy-1-(hydroxy-oxido-phosphoryl)- butyl]phosphonic acid, trihydrate; MK-217; Fosamax

Appearance: White solid

Formulation: N/A

CAS Number: 121268-17-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄H₁₂NaNO₇P₂ · 3 H₂O

Molecular Weight: 325.12

Cell-Permeable?: No

Purity: ≥95%

Solubilities: H₂O (10 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A specific inhibitor of osteoclast-mediated bone resorption

MDL Number: MFCD01748233

PubChem CID: 23681107

SMILES: C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.O.O.O.[Na+]

InChi: InChI=1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1

InChi Key: DCSBSVSZJRSITC-UHFFFAOYSA-M