Alix, Human Recombinant | P1576

Alix, also known as PDCD6IP, is a cytoplasmic protein that interacts with apoptosis-associated proteins (ALG-2 and PDCD6) and with the endocytosis-regulator CIN85. It's involved in concentration and sorting of cargo proteins of the multivesicular body for incorporation into intralumenal vesicles that are generated by invagination and scission from the limiting membrane of the endosome. Overexpression of this protein and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death. Recombinant PDCD6IP protein was expressed in E. coli and purified by using conventional chromatography techniques.

P1576 | Alix, Human Recombinant DataSheet

Biomolecule/Target :

Synonyms: Programmed cell death 6 interacting protein, AIP1, PDCD6IP, DRIP4, HP95

Alternates names: Programmed cell death 6 interacting protein, AIP1, PDCD6IP, DRIP4, HP95

Taglines: Cytoplasmic protein that interacts with apoptosis-associated proteins

NCBI Gene ID #: 10015

NCBI Gene Symbol: PDCD6IP

Gene Source: Human

Accession #: Q8WUM4

Recombinant: TRUE

Source: E. coli

Purity by SDS-PAGE: >95%

Assay: SDS - PAGE

Purity:

Assay #2:

Endotoxin Level:

Activity (Specifications/test method):

Biological activity:

Results:

Binding Capacity:

Unit Definition:

Molecular Weight: 45.8 kDa (412aa) (N terminal His -Tag)

Concentration:

Appearance: Liquid

Physical form description: In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 1 mM DTT

Reconstitution Instructions:

Amino acid sequence: aa 1-392

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans