Allopregnanolone | B2385

Allopregnanolone is an endogenous inhibitory pregnane neurosteroid that is synthesized from progesterone. It acts as a positive allosteric modulator of GABAA receptors at nM concentrations and of GABAC receptors at µM concentrations. Allopregnanolone displays effects similar to other GABAA receptor potentiators such as benzodiazepines, including potent anticonvulsant, anxiolytic, and sedative activity.

Allopregnanolone is an endogenous inhibitory pregnane neurosteroid that is synthesized from progesterone. It acts as a positive allosteric modulator of GABAA receptors at nM concentrations and of GABAC receptors at µM concentrations. Allopregnanolone displays effects similar to other GABAA receptor potentiators such as benzodiazepines, including potent anticonvulsant, anxiolytic, and sedative activity.

B2385 | Allopregnanolone DataSheet

Alternate Name/Synonyms: 3α-hydroxy-5α-pregnan-20-one, ALLO, 3α-Hydroxy-5α-pregnan-20-one;3α-OH-DHP; Allopregnan-3α-ol-20-one; 5α-Pregnan-3α-ol-20-one

Appearance: White solid

Formulation:

CAS Number: 516-54-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₁H₃₄O₂

Molecular Weight: 318.49

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >25 mg/ml in Ethanol, >25 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line:

MDL Number: MFCD00003677

PubChem CID: 92786

SMILES: CC(=O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C

InChi: InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16-,17+,18-,19-,20-,21+/m0/s1

InChi Key: AURFZBICLPNKBZ-SYBPFIFISA-N