Alpelisib | B1271

Alpelisib (also known as BYL719), is a potent and selective phosphatidylinositol-3 kinase α inhibitor. It inhibits P110α, p110β, p110δ, and p110g with IC₅₀ values of 5 nM, 1.2 µM, 0.29 µM and 0.25 µM, respectively, in biochemical assays. It inhibits the Akt phosphorylation with IC₅₀ values of 74 nM in Rat1-myr-p110α cells, 2.2 µM in Rat1-myr-p110β cells, and 1.2 µM in Rat1-myr-p110δ cells.

Alpelisib (also known as BYL719), is a potent and selective phosphatidylinositol-3 kinase α inhibitor. It inhibits P110α, p110β, p110δ, and p110g with IC₅₀ values of 5 nM, 1.2 µM, 0.29 µM and 0.25 µM, respectively, in biochemical assays. It inhibits the Akt phosphorylation with IC₅₀ values of 74 nM in Rat1-myr-p110α cells, 2.2 µM in Rat1-myr-p110β cells, and 1.2 µM in Rat1-myr-p110δ cells.

B1271 | Alpelisib DataSheet

Alternate Name/Synonyms: (S)-N1-(4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide; BYL719

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1217486-61-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₂F₃N₅O₂S

Molecular Weight: 441.47

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective phosphatidylinositol-3 kinase α inhibitor

MDL Number: N/A

PubChem CID: 56649450

SMILES: CC1=C(SC(=N1)NC(=O)N2CCCC2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F

InChi: InChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1

InChi Key: STUWGJZDJHPWGZ-LBPRGKRZSA-N