Alpha 1 Acid Glycoprotein, Human Plasma | 7547

Found in human plasma in concentrations of 55-140 mg per 100 ml. Classical standard glycoprotein for studies on the structure of the oligosaccharide units. Carbohydrate content is 40%. Its biological significance is unknown although it can bind progesterone 15 times as strongly as albumin. Sialic-acid-deficient alpha-1-AG has an affinity for vitamin B-12. Clinically, alpha 1 acid glycoprotein is an acute-phase reactant that together with haptoglobin is an indicator of acute inflammation. The alpha 1 acid glycoprotein: haptoglobin ratio is useful in studies of bone marrow disorders, hemolytic processes and metastases.

7547 | Alpha 1 Acid Glycoprotein Human Plasma DataSheet

Biomolecule/Target: Alpha 1 Acid Glycoprotein

Synonyms: AGP, Orosomucoid

Alternates names: AGP, Orosomucoid

Taglines: An acute-phase reactant that together with haptoglobin is an indicator of acute inflammation.

NCBI Gene ID #: 115650

NCBI Gene Symbol: TR13C

Gene Source: Human

Accession #: Q96RJ3

Recombinant: No

Source: Human Plasma

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Determined by its ability to block BAFF induced mouse splenocyte survival. The expected ED for this effect is typically 1-5 µg/ml in the presence of 1 µg/ml human soluble BAFF.

Results: 120 units/mg protein.

Binding Capacity: N/A

Unit Definition: One unit is defined as the amount of enzyme which will hydrolyze 1 µmole of N-tosyl-L-arginine methyl ester in 30 minutes at 37°C at pH 8.0.

Molecular Weight: 7.7 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized as a salt free solid.

Reconstitution Instructions: Reconstitute in sterile HO to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers or stored at 4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A