Alpha 1 Antitrypsin, Human Plasma | 7294

Alpha 1 Antitrypsin is an acute-phase plasma protein found at 290 mg per 100 ml. It functions as a serine protease inhibitor with targets like elastase, plasmin, collagenase, thrombin, leucocyte proteases, trypsin, chymotrypsin, and plasminogen activator. Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis. It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives. The simultaneous quantitative determination of alpha-1-PI and ceruloplasmin permits differential diagnosis of liver afflictions. Rise in alpha 1 antitrypsin occurs as an acute phase response to tissue necrosis and inflammation.

7294 | Alpha 1 Antitrypsin Human Plasma DataSheet

Biomolecule/Target: Serpin A1

Synonyms: Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, AAT, PI

Alternates names: Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, AAT, PI

Taglines: An acute-phase plasma protein

NCBI Gene ID #: 5265

NCBI Gene Symbol: Serpin A1

Gene Source: Human

Accession #: P01009

Recombinant: No

Source: Human Plasma

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Shows 75-100% inhibition when tested with active-site titrated porcine pancreatic trypsin using Na-Benzoyl-L-Arginine-para-Nitroanilide Hydrochloride (L-BAPNA) as substrate.

Results: 5.0 IU/mg

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 52 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 30 mM Na Phosphate, pH 6.5 with 300 mM NaCl.

Reconstitution Instructions: In water or aqueous buffer

Amino acid sequence: N/A