Alpha 2 Antiplasmin, Human Plasma | 7295

Alpha 2 Antiplasmin is a member of the Serpin superfamily and the primary physiological inhibitor of the serine protease plasmin, which is responsible for the dissolution of fibrin clots. In addition to plasmin, it is also an efficient inhibitor of trypsin and chymotrypsin. Liver and kidney are major sites of its production and other tissues such as muscle, intestine, central nervous system, and placenta also express its mRNA at a moderate level. The tissue expression pattern indicates that it is a key regulator of plasmin mediated proteolysis in these tissues. Alpha-Antiplasmin-deficiency is a rare coagulation disorder which allows unrestrained fibrinolytic activity. Individuals with this condition may receive therapeutic A2AP prior to surgery to prevent postoperative hemorrhaging.

7295 | Alpha 2 Antiplasmin Human Plasma DataSheet

Biomolecule/Target: SERPINF2

Synonyms: Alpha-2-plasmin inhibitor, SERPINF2, AAP, PLI

Alternates names: Alpha-2-plasmin inhibitor, SERPINF2, AAP, PLI

Taglines: Physiological inhibitor of the serine protease plasmin.

NCBI Gene ID #: 5345

NCBI Gene Symbol: SERPINF2

Gene Source: Human

Accession #: P08697

Recombinant: No

Source: Human Plasma

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 70 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 20 mM Bis-Tris, pH 6.4, with 200 mM NaCl.

Reconstitution Instructions: In water or aqueous buffer

Amino acid sequence: N/A