Alsterpaullone | 1897

Cell-permeable. A potent inhibitor of CDK1/cyclin B (IC₅₀ =35 nM). Also inhibits CDK2/cyclin A, CDK2/cyclin E (IC₅₀ = 200 nM), CDK5/p25 (IC₅₀ = 40 nM), CDK5/p35 (IC₅₀ = 40 nM) and GSK-3β.

Alsterpaullone is a potent inhibitor of CDK1/cyclin B (IC₅₀ =35 nM). Also inhibits CDK2/cyclin A, CDK2/cyclin E (IC₅₀ = 200 nM), CDK5/p25 (IC₅₀ = 40 nM), CDK5/p35 (IC₅₀ = 40 nM) and GSK-3β.

1897 | Alsterpaullone DataSheet

Alternate Name/Synonyms: 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one

Appearance: Yellow to brown solid

Formulation: N/A

CAS Number: 237430-03-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₁N₃O₃

Molecular Weight: 293.28

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent inhibitor of CDK1/cyclin B

MDL Number: MFCD02683579

PubChem CID: 5005498

SMILES: C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)[N+](=O)[O-]

InChi: InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3- 1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)

InChi Key: OLUKILHGKRVDCT-UHFFFAOYSA-N