Alvimopan | B2472

Alvimopan is a peripherally acting μ-opioid receptor antagonist (Ki = 0.47 nM) that is selective over the κ- and δ-opioid receptors (Ki's = 100 nM and 12 nM, respectively). It is used to avoid postoperative ileus following small or large bowel resection and accelerates the gastrointestinal recovery period.

Alvimopan is a peripherally acting μ-opioid receptor antagonist (Ki = 0.47 nM) that is selective over the κ- and δ-opioid receptors (Ki's = 100 nM and 12 nM, respectively). It is used to avoid postoperative ileus following small or large bowel resection and accelerates the gastrointestinal recovery period.

B2472 | Alvimopan DataSheet

Alternate Name/Synonyms: ADL 8-2698; N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-glycine; LY246736

Appearance: Crystalline solid

Formulation:

CAS Number: 156053-89-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₃₂N₂O₄

Molecular Weight: 424.5

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~20 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A peripherally acting μ-opioid receptor antagonist

MDL Number:

PubChem CID: 5488548

SMILES: CC1CN(CCC1(C)C2=CC(=CC=C2)O)CC(CC3=CC=CC=C3)C(=O)NCC(=O)O

InChi: InChI=1S/C25H32N2O4/c1-18-16-27(12-11-25(18,2)21-9-6-10-22(28)14-21)17-20(24(31)26-15-23(29)30)13-19-7-4-3-5-8-19/h3-10,14,18,20,28H,11-13,15-17H2,1-2H3,(H,26,31)(H,29,30)/t18-,20-,25+/m0/s1

InChi Key: UPNUIXSCZBYVBB-JVFUWBCBSA-N