AM-095 Sodium | B1225

AM-095 is a potent LPA1 receptor antagonist with IC₅₀ values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively. In functional assays, AM-095 inhibits LPA-driven chemotaxis of CHO cells overexpressing mouse LPA₁ (IC₅₀ = 778 nM) and human A2058 melanoma cells (IC₅₀ = 233 nM).

AM-095 is a potent LPA1 receptor antagonist with IC₅₀ values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively. In functional assays, AM-095 inhibits LPA-driven chemotaxis of CHO cells overexpressing mouse LPA₁ (IC₅₀ = 778 nM) and human A2058 melanoma cells (IC₅₀ = 233 nM).

B1225 | AM-095 Sodium DataSheet

Alternate Name/Synonyms: Sodium (R)-2-(4'-(3-methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acetate

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1345614-59-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₂₃N₂NaO₅

Molecular Weight: 478.47

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent LPA1 receptor antagonist

MDL Number: N/A

PubChem CID: 76003789

SMILES: CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)CC(=O)[O-].[Na+]

InChi: InChI=1S/C27H24N2O5.Na/c1-17-25(28-27(32)33-18(2)20-6-4-3-5-7-20)26(34-29-17)23-14-12-22(13-15-23)21-10-8-19(9-11-21)16-24(30)31;/h3-15,18H,16H2,1-2H3,(H,28,32)(H,30,31);/q;+1/p-1

InChi Key: BDKDADFSIDCQGB-UHFFFAOYSA-M