AM-251 | B2718

AM251 is a selective cannabinoid 1 (CB1) receptor antagonist with an IC50 of 8 nM. It also acts as an agonist at GPR55 (EC50 = 39 nM) and potentiates GABAA receptor currents (EC50 = 0.4 µM). In mice, AM251 reduces antidepressant-like behavior in the tail suspension and forced swim tests and decreases hyperphagia induced by fasting.

AM251 is a selective cannabinoid 1 (CB1) receptor antagonist with an IC50 of 8 nM. It also acts as an agonist at GPR55 (EC50 = 39 nM) and potentiates GABAA receptor currents (EC50 = 0.4 µM). In mice, AM251 reduces antidepressant-like behavior in the tail suspension and forced swim tests and decreases hyperphagia induced by fasting.

B2718 | AM-251 DataSheet

Alternate Name/Synonyms: 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide,AM251

Appearance: White to off-white solid

Formulation:

CAS Number: 183232-66-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₁Cl₂IN₄O

Molecular Weight: 555.24

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >20 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective cannabinoid 1 (CB1) receptor antagonist

MDL Number: MFCD01861181

PubChem CID: 2125

SMILES: Ic1ccc(cc1)c1c(C)c(nn1c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1

InChi: InChI=1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)

InChi Key: BUZAJRPLUGXRAB-UHFFFAOYSA-N