AM580 | 2635

AM580 is an analog of Retinoic acid (Cat. No. 2218) that acts as aretinoic acid receptor agonist that is selective for RARα (Kd = 8 nM; AC₅₀ = 0.36 nM) compared to RARβ (Kd = 131 nM; AC₅₀ = 24.6 nM) and RARγ (Kd = 450 nM; AC₅₀ = 27.9 nM). It displays greater specific binding to RARα compared to retinoic acid which exhibits little selectivity across RARα, β, or γ. AM580 has been used in combination with the GSK3β inhibitor CHIR99021 (Cat. No.1677) to efficiently induce differentiation of human induced pluripotent stem cells into immediate mesoderm.

AM580 is an analog of Retinoic acid (Cat. No. 2218) that acts as aretinoic acid receptor agonist that is selective for RARα (Kd = 8 nM; AC₅₀ = 0.36 nM) compared to RARβ (Kd = 131 nM; AC₅₀ = 24.6 nM) and RARγ (Kd = 450 nM; AC₅₀ = 27.9 nM). It displays greater specific binding to RARα compared to retinoic acid which exhibits little selectivity across RARα, β, or γ. AM580 has been used in combination with the GSK3β inhibitor CHIR99021 (Cat. No.1677) to efficiently induce differentiation of human induced pluripotent stem cells into immediate mesoderm.

2635 | AM580 DataSheet

Alternate Name/Synonyms: 4-​​[[(5,​​6,​​7,​​8-​​tetrahydro-​​5,​​5,​​8,​​8-​​tetramethyl-​​2-​​naphthalenyl)​carbonyl]​amino]​-​benzoic acid; RO 40-6055; CD336; NSC 608001

Appearance: White solid

Formulation: N/A

CAS Number: 102121-60-8

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₅NO₃

Molecular Weight: 351.44

Cell-Permeable?: Yes

Purity: >98%

Solubilities: DMSO (~ 15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective RARα agonist and stem cell fate modulator

MDL Number: MFCD00673916

PubChem CID: 2126

SMILES: CC1(CCC(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)(C)C)C

InChi: nChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)

InChi Key: SZWKGOZKRMMLAJ-UHFFFAOYSA-N