Description
AMG-708 is a selective small-molecule inhibitor (IC₅₀ = 9.3 nM) of the proto-oncogene c-Met with potential antineoplastic activity. AMG 208 inhibits the ligand-dependent and ligand-independent activation of c-Met, inhibiting its tyrosine kinase activity, which may result in cell growth inhibition in tumors that overexpress c-Met.
AMG-708 is a selective small-molecule inhibitor (IC₅₀ = 9.3 nM) of the proto-oncogene c-Met with potential antineoplastic activity. AMG 208 inhibits the ligand-dependent and ligand-independent activation of c-Met, inhibiting its tyrosine kinase activity, which may result in cell growth inhibition in tumors that overexpress c-Met.
Alternate Name/Synonyms: 7-methoxy-4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 1002304-34-8
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₁₇N₅O₂
Molecular Weight: 383.4
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~ 1 mg in ml) or EtOH (~ 1 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A c-Met inhibitor
MDL Number: N/A
PubChem CID: 24864821
SMILES: COC1=CC2=NC=CC(=C2C=C1)OCC3=NN=C4N3N=C(C=C4)C5=CC=CC=C5
InChi: InChI=1S/C22H17N5O2/c1-28-16-7-8-17-19(13-16)23-12-11-20(17)29-14-22-25-24-21-10-9-18(26-27(21)22)15-5-3-2-4-6-15/h2-13H,14H2,1H3
InChi Key: HEAIZQNMNCHNFD-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |
