AMG-337 | B3317

AMG-337 is a potent and selective inhibitor of c-Met kinase activity (IC50 = 1 nM) and adaptor protein Gab-1 phosphorylation, that subsequently blocks downstream PI3K and MAPK pathways. It has been shown to inhibit hepatocyte growth factor-mediated c-Met phosphorylation in PC3 cells (IC50 = 5 nM) and to block tumor growth in a c-Met-dependent xenograft model in mice (ED50 = 0.3 mg/kg).

AMG-337 is a potent and selective inhibitor of c-Met kinase activity (IC50 = 1 nM) and adaptor protein Gab-1 phosphorylation, that subsequently blocks downstream PI3K and MAPK pathways. It has been shown to inhibit hepatocyte growth factor-mediated c-Met phosphorylation in PC3 cells (IC50 = 5 nM) and to block tumor growth in a c-Met-dependent xenograft model in mice (ED50 = 0.3 mg/kg).

B3317 | AMG-337 DataSheet

Alternate Name/Synonyms: 6-[(1R)-1-[8-fluoro-6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyridin-5-one AMG337

Appearance: Crystalline solid

Formulation:

CAS Number: 1173699-31-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₂FN₇O₃

Molecular Weight: 463.5

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >30 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A c-Met kinase inhibitor

MDL Number:

PubChem CID: 44181686

SMILES: CC(C1=NN=C2N1C=C(C=C2F)C3=CN(N=C3)C)N4C=CC5=C(C4=O)C=C(C=N5)OCCOC

InChi: InChI=1S/C23H22FN7O3/c1-14(30-5-4-20-18(23(30)32)9-17(11-25-20)34-7-6-33-3)21-27-28-22-19(24)8-15(13-31(21)22)16-10-26-29(2)12-16/h4-5,8-14H,6-7H2,1-3H3/t14-/m1/s1

InChi Key: DWHXUGDWKAIASB-CQSZACIVSA-N