Description
AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, also inhibits PI3Kγ with IC50 of 850 nM.
AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, also inhibits PI3Kγ with IC50 of 850 nM.
Alternate Name/Synonyms: AMG319, AMG319; AMG 319; N-[(1S)-1-(7-fluoro-2-pyridin-2-ylquinolin-3-yl)ethyl]-7H-purin-6-amine; (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine
Appearance: Solid
Formulation: N/A
CAS Number: 1608125-21-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₁H₁₆FN₇
Molecular Weight: 385.4
Cell-Permeable?: Yes
Purity: >98%
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A highly selective inhibitor of phosphoinositide 3-kinase p110δ isoform
MDL Number: N/A
PubChem CID: 68947304
SMILES: CC(C1=C(N=C2C=C(C=CC2=C1)F)C3=CC=CC=N3)NC4=NC=NC5=C4NC=N5
InChi: InChI=1S/C21H16FN7/c1-12(28-21-19-20(25-10-24-19)26-11-27-21)15-8-13-5-6-14(22)9-17(13)29-18(15)16-4-2-3-7-23-16/h2-12H,1H3,(H2,24,25,26,27,28)/t12-/m0/s1
InChi Key: KWRYMZHCQIOOEB-LBPRGKRZSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |