AMHR2 polyclonal Antibody | BS6322

AMHR2 polyclonal Antibody | BS6322 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ELISA

Application Range: WB 1:500 - 1:2000 ELISA 1:5000 - 1:10000

Background: MISR II (anti-Muellerian hormone type-2 receptor, MIS type II receptor) is a 573 amino acid protein encoded by the human gene AMHR2. MISR II belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily and contains one protein kinase domain. Upon ligand binding, MISR II forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. These type II receptors phospho-rylate and activate type I receptors which autophosphorylate, then bind and activate Smad transcriptional regulators. MISR II also acts as a receptor for anti-Muellerian hormone. Defects in AMHR2 are the cause of persistent Muellerian duct syndrome type 2 (PMDS-2) . PMDS-2 is a form of male pseudo-hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: AMHR2 polyclonal Antibody detects endogenous levels of AMHR2 protein.

Molecular Weight: ~ 63 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Anti-Muellerian hormone type-2 receptor; Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII; AMHR2; AMHR; MISR2

Immunogen: KLH conjugated synthetic peptide derived from human MISRII/AMHR2: 21-120/573

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Cell Cycle G2 M DNA Damage Signaling Pathway,