AMI-1 | 1943

Cell-permeable. A potent and specific protein arginine N-methyltransferase (PRMTs) inhibitor (IC₅₀ = 8.8 μM for human PRMT1 and 3.0 μM for yeast Hmt1p ). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Also acts as a HIV-1 RT polymerase inhibitor (IC₅₀ = 5.0 μM).

AMI-1 is a potent and specific protein arginine N-methyltransferase (PRMTs) inhibitor (IC₅₀ = 8.8 μM for human PRMT1 and 3.0 μM for yeast Hmt1p ). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Also acts as a HIV-1 RT polymerase inhibitor (IC₅₀ = 5.0 μM).

1943 | AMI-1 DataSheet

Alternate Name/Synonyms: Arginine N-methyltransferase inhibitor-1

Appearance: Brown solid

Formulation: N/A

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₂N₂O₉S₂Na₄

Molecular Weight: 592.42

Cell-Permeable?: Yes

Purity: ≥98% by NMR

Solubilities: DMSO or Ethanol or water

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent and specific protein arginine N-methyltransferase (PRMTs) inhibitor

MDL Number: N/A

PubChem CID: 16760626

SMILES: C1=CC2=C(C=C(C=C2C=C1NC(=O)NC3=CC4=CC(=CC(=C4C=C3)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])[O-].[Na+].[Na+].[Na+].[Na+]

InChi: InChI=1S/C21H16N2O9S2.4Na/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32;;;;/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32);;;;/q;4*+1/p-4

InChi Key: OEJIOAHFKHHDAW-UHFFFAOYSA-J