AMI-5 | 2300

AMI-5 is a non-specific small molecule inhibitor of protein arginine methyltransferases (PRMTs) (IC₅₀ = 0.78 and 1.41 µM against Hmt1p and PRMT1, respectively) and histone lysine methyltransferases (HKMTs) (DOT1 and SET7, but not Suv39H1 and Suv39H2).

AMI-5 is a non-specific small molecule inhibitor of protein arginine methyltransferases (PRMTs) (IC₅₀ = 0.78 and 1.41 µM against Hmt1p and PRMT1, respectively) and histone lysine methyltransferases (HKMTs) (DOT1 and SET7, but not Suv39H1 and Suv39H2).

2300 | AMI-5 DataSheet

Alternate Name/Synonyms: 2′,4′,5′,7′-Tetrabromofluorescein disodium salt, Acid Red 87, Bromo acid J. TS, XL, or XX, Bromofluorescein, Bronze Bromo ES, Eosin yellowish

Appearance: Brown to dark red solid

Formulation: N/A

CAS Number: 17372-87-1

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₂₀H₆Br₄Na₂O₅

Molecular Weight: 691.85

Cell-Permeable?: No

Purity: ≥90% (based on the anhydrous material)

Solubilities: H2O (1 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A protein methyltransferase inhibitor

MDL Number: MCFD00005040

PubChem CID: 11048

SMILES: C1=CC=C(C(=C1)C2=C3C=C(C(=O)C(=C3OC4=C(C(=C(C=C24)Br)[O-])Br)Br)Br)C(=O)[O-].[Na+].[Na+]

InChi: InChI=1S/C20H8Br4O5.2Na/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25;;/h1-6,25H,(H,27,28);;/q;2*+1/p-2

InChi Key: SEACYXSIPDVVMV-UHFFFAOYSA-L