Amidepsine A, Humcola sp. | 2147

A diacylglycerol acyltransferase (DGAT) inhibitor. Shows inhibitory effect in rat liver microsomes (IC₅₀ = 10.2 µM) and Raji cells (IC₅₀ = 15.5 µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.

Amidepsine A, Humcola sp. is a diacylglycerol acyltransferase (DGAT) inhibitor. Shows inhibitory effect in rat liver microsomes (IC₅₀ = 10.2 µM) and Raji cells (IC₅₀ = 15.5 µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.

2147 | Amidepsine A, Humcola sp. DataSheet

Alternate Name/Synonyms: N-[4-[[4-[(2,4-Dimethoxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methylbenzoyl]oxy]-2-hydroxy-6-methylbenzoyl]-L-alanine

Appearance: Off-white solid

Formulation: N/A

CAS Number: 169181-28-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₂₉NO₁₁

Molecular Weight: 567.55

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO or EtOH

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A diacylglycerol acyltransferase (DGAT) inhibitor

MDL Number: N/A

PubChem CID: 10099481

SMILES: CC1=CC(=CC(=C1C(=O)NC(C)C(=O)O)O)OC(=O)C2=C(C=C(C=C2C)OC(=O)C3=C(C=C(C=C3C)OC)OC)O

InChi: InChI=1S/C29H29NO11/c1-13-8-18(10-20(31)23(13)26(33)30-16(4)27(34)35)40-28(36)24-14(2)9-19(11-21(24)32)41-29(37)25-15(3)7-17(38-5)12-22(25)39-6/h7-12,16,31-32H,1-6H3,(H,30,33)(H,34,35)

InChi Key: XQGKRCPZJSNFEL-UHFFFAOYSA-N