Aminopurvalanol A | 2205

A cell-permeable, reversible and competitive inhibitor of cyclin-dependent kinases. IC₅₀ values are: CDK1/cyclin B (33 nM), CDK2/cyclin A (33 nM), CDK2/cyclin E (28 nM) and CDK5/p35 (20 nM).

Aminopurvalanol A is a cell-permeable, reversible and competitive inhibitor of cyclin-dependent kinases.

2205 | Aminopurvalanol A DataSheet

Alternate Name/Synonyms: (2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol; NG97

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 220792-57-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₆ClN₇O

Molecular Weight: 403.91

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (100 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A CDK inhibitor

MDL Number: MFCD06798384

PubChem CID: 6604931

SMILES: CC(C)C(CO)NC1=NC2=C(C(=N1)NC3=CC(=CC(=C3)N)Cl)N=CN2C(C)C

InChi: InChI=1S/C19H26ClN7O/c1-10(2)15(8-28)24-19-25-17(23-14-6-12(20)5-13(21)7-14)16-18(26-19)27(9-22-16)11(3)4/h5-7,9-11,15,28H,8,21H2,1-4H3,(H2,23,24,25,26)/t15-/m0/s1

InChi Key: RAMROQQYRRQPDL-HNNXBMFYSA-N