Amlodipine besylate | 2378

A L-type calcium channel blocker and an anti-hypertensive agent. Amlodipine displays vasoprotective effects in cardiovascular disease and inhibits Ca²⁺-induced contractions in depolarized rat aorta (IC₅₀ = 1.9 nM). Amlodipin also inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC₅₀ = 25 μM).

Amlodipine is a L-type calcium channel blocker and an anti-hypertensive agent.

2378 | Amlodipine besylate DataSheet

Alternate Name/Synonyms: 2-[(2-Aminoethoxy)methyl]-4-(2-chlo­rophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarbo­xylic acid 3-ethyl 5-methyl ester benzenesulfonate

Appearance: White solid

Formulation: N/A

CAS Number: 111470-99-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₅ClN₂O₅.C₆H₆O₃S

Molecular Weight: 567.05

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~100 mM) or H₂O (~10 mM)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A calcium channel blocker

MDL Number: MFCD00887594

PubChem CID: 60496

SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O

InChi: InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)

InChi Key: ZPBWCRDSRKPIDG-UHFFFAOYSA-N