AmoyDx® BRA F V600 Mutations Detection Kit | 8.01.20302X024/8.0120303X024

AmoyDx® BRA F V600 Mutations Detection Kit | 8.01.20302X024/8.0120303X024 | Gentaur UK, US & Europe Distribution  

BRAF is a serine/threonine kinase that functions within the Ras-Raf-MEK-MAPK pathway. This pathway normally regulates cell proliferation and survival under the control of growth factors and hormones. Mutations in the BRAF gene have been associated with the development of cancer. The most common alteration in the BRAF gene is a mutation called V600E, which alters the valine at position 600 in the protein to a glutamic acid. Other mutations observed at the V600 position are V600D, V600K and V600R. These mutations cause the BRAF protein to be permanently activated, even in the absence of growth factors, resulting in excessive cell proliferation and resistance to apoptosis. BRAF mutations occur in 〜50% of melanoma tumors,〜40% of papillary thyroid tumors, ~30% of ovarian tumors,〜10% of colorectal tumors,〜10% of prostate tumors and 1 〜4% of non-small cell lung cancer. The search for drugs that block oncogenic BRAF signaling is an active area of pharmaceutical research and development.

Testing Procedure