AMDX

AmoyDx® EML4-ALK Fusion Gene Detection Kit | 8.01.22001X024H

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SKU:
AMDX-AM-8.01.22001X024H-GEN
Availability:
IN STOCK
zł6,600.00

Description

AmoyDx® EML4-ALK Fusion Gene Detection Kit | 8.01.22001X024H | Gentaur UK, US & Europe Distribution  

The anaplastic lymphoma kinase (ALK) gene is frequently involved in rearrangements that lead to gene fusions in lung cancer. Fusion partner of echinoderm microtubule-associated protein-like 4 (EML4) is frequently found in non-small-cell lung cancer (NSCLC). The recombinant EML4-ALK activates the receptor tyrosine kinase's downstream signaling pathway, which includes PI3K/AKT, leading to carcinogenesis. It has been reported that the presence of the EML4-ALK fusion is correlated with the efficacy of 4LK-targeted therapy. Based on analysis of tumor messenger RNA, EML4-ALK fusions can be detected by real-time PCR method.

Intended Use

AmoyDx® EML4-ALK Fusion Gene Detection Kit is a real-time PCR assay for qualitative detection of 21 EML4-ALK fusions in total RNA extracted from formalin-fixed paraffin-embedded (FFPE) tumor tissue in NSCLC patients.

The kit is for research use only, and intended to be used by trained professionals in a laboratory environment.

Testing Procedure

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Additional Information

Size:
24 Tests/Kit
Type:
Bulk
Status:
CE marked
PCR Instrument (stated in IFU):
Stratagene Mx3000P™, ABI 7500, LightCycler480 II, Bio-Rad CFX96, Rotor-Gene Q/6000 (72 wells), SLAN-96S
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