AMPKβ2 Polyclonal Antibody | ABP57261

AMPKβ2 Polyclonal Antibody | ABP57261 | Gentaur UK, US & Europe Distribution

Immunogen: Recombinant Protein

Product Category: Protein

Application: Protein General Reagents

Product Type: Primary Antibody

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB

Application Note: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:1000-1:2000) .

Clonality: Polyclonal

Isotype: Rabbit IgG

Formulation: Liquid solution

Kit Component: N/A

Concentration: 1 mg/ml

Storage Buffer: PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol.

Storage Instructions: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Shipping Condition: Gel pack with blue ice.

Background: The protein encoded by PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2) is a regulatory subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for PRKAB2.

Alternative Names: N/A

Precaution: The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.