AMTB hydrochloride | B2978

AMTB is an antagonist of transient receptor potential melastatin 8 (TRPM8). It inhibits icilin-induced calcium influx with a pIC₅₀ of 6.23. Intravenous administration of AMTB (3 mg/kg) decreases the frequency of volume-induced urinary bladder contractions, without reducing the amplitude of contraction in a rat model. It inhibits the response to noxious bladder stimulation at 10 mg/kg. AMTB also inhibits the sodium channel (Nav) isoforms Nav1.1-1.9 with IC₅₀ values of 2 µM-14.8 µM and decreases viability of MDA-MB-231 and SK-BR-3 breast cancer cells with IC₅₀ values of ~23.7 µM and 17.3 µM, respectively in a TRPM8-independent manner.

AMTB is an antagonist of transient receptor potential melastatin 8 (TRPM8). It inhibits icilin-induced calcium influx with a pIC₅₀ of 6.23. Intravenous administration of AMTB (3 mg/kg) decreases the frequency of volume-induced urinary bladder contractions, without reducing the amplitude of contraction in a rat model. It inhibits the response to noxious bladder stimulation at 10 mg/kg. AMTB also inhibits the sodium channel (Nav) isoforms Nav1.1-1.9 with IC₅₀ values of 2 µM-14.8 µM and decreases viability of MDA-MB-231 and SK-BR-3 breast cancer cells with IC₅₀ values of ~23.7 µM and 17.3 µM, respectively in a TRPM8-independent manner.

B2978 | AMTB hydrochloride DataSheet

Alternate Name/Synonyms: N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(thiophen-2-ylmethyl)benzamide, hydrochloride; N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)-benzamide, monohydrochloride; N-(3-aminopropyl)-2-((3-methylbenzyl)oxy)-N-(thiophen-2-ylmethyl)benzamide hydrochloride

Appearance: Solid

Formulation:

CAS Number: 926023-82-7

Structure Available?: True

Peptide sequence:

Salt Form: true

Molecular Formula: C₂₃H₂₇ClN₂O₂S

Molecular Weight: 430.99

Cell-Permeable?: True

Purity: 99%

Solubilities: ~40 mg/ml in water and DMSO in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An antagonist of TRPM8

MDL Number:

PubChem CID: 16095383

SMILES: CC1=CC(=CC=C1)COC2=CC=CC=C2C(=O)N(CCCN)CC3=CC=CS3.Cl

InChi: InChI=1S/C23H26N2O2S.ClH/c1-18-7-4-8-19(15-18)17-27-22-11-3-2-10-21(22)23(26)25(13-6-12-24)16-20-9-5-14-28-20;/h2-5,7-11,14-15H,6,12-13,16-17,24H2,1H3;1H

InChi Key: UDXGBANGPYONOK-UHFFFAOYSA-N