Amuvatinib | 9458

Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC₅₀ values of 10 nM, 40 nM and 81 nM, respectively. It also disrupts DNA repair likely through suppression of Homologous Recombination protein Rad51.

Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC₅₀ values of 10 nM, 40 nM and 81 nM, respectively. It also disrupts DNA repair likely through suppression of Homologous Recombination protein Rad51.

9458 | Amuvatinib DataSheet

Alternate Name/Synonyms: N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide; MP-470; HPK56

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 850879-09-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₃H₂₁N₅O₃S

Molecular Weight: 447.51

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A multi-targeted tyrosine kinase inhibitor

MDL Number: N/A

PubChem CID: 11282283

SMILES: C1CN(CCN1C2=NC=NC3=C2OC4=CC=CC=C43)C(=S)NCC5=CC6=C(C=C5)OCO6

InChi: InChI=1S/C23H21N5O3S/c32-23(24-12-15-5-6-18-19(11-15)30-14-29-18)28-9-7-27(8-10-28)22-21-20(25-13-26-22)16-3-1-2-4-17(16)31-21/h1-6,11,13H,7-10,12,14H2,(H,24,32)

InChi Key: FOFDIMHVKGYHRU-UHFFFAOYSA-N