Amyloid beta oligomer-specific monoclonal antibody (OMAB) | AS10 932

Amyloid beta oligomer-specific monoclonal antibody (OMAB) | AS10 932 | Gentaur UK, US & Europe Distribution

Immunogen: partly aggregated, recombinant peptide corresponding to the human Abeta (1-40/42), Amino acid sequence: D-A-E-F-R-H-D-S-G-Y-E-V-H-H-Q-K-L-V-F-F-A-E-D-V-G-S-N-K-G-A-I-I-G-L-M-V-G-G-V-V, The epitope is 3-8, Molecular weight of immunogen is 4, 5 kDa,

Host: Mouse

Conjugation: N/A

Clonality: Monoclonal

Isotype: IgM

Purity: Affinity purified in PBS pH 7.4.

Format: Lyophilized

Tested Application: ELISA (ELISA), Immunofluorescence (IF), Immunohistochemistry (IHC)

Related Products: AS13 2716 | mAB-M | human Abeta protein (3-10) region, oligomer-specific, mouse monoclonal antibodyAS13 2715 | mAB-O | human Abeta protein (3-10) region, oligomer specific, mouse monoclonal antibodyAS10 932B | Amyloid beta oligomer-specific monoclonal antibody (OMAB), BiotinylatedAgrisera matching secondary antibody: Goat anti-mouse IgM (µ chain), HRP conjugated, min. cross-reactivity to human IgG/serum, AS10 969Secondary antibodies

Recommended Dilutions: Coating antibody at 2 µg/ml (ELISA), 1: 1000 (IF), 1 : 500 (IHC)

Molecular weight: 4, 5 kDa

Confirmed Reactivity: Human Abeta oligomers only

Predicted Reactivity: Rat

Not reactive in: No confirmed exceptions from predicted reactivity are currently known

Additional Information: OMAB antibody is a versatile tool within research of Alzheimer's disease, A sandwhich ELISA illustrates its potential regarding its high selectivity towards A? oligomers

Background: Soluble oligomeric assemblies of the Amyloid-β peptide are today anticipated to be the direct cause regarding the Alzheimer pathology. As a consequence, oligomeric Aβ-assemblies constitute a very interesting therapeutic target. Identification of Aβ-oligomers is however, technically challenging due to there labile nature and low abundance. Abeta oligomer-specific OMAB antibody is based on the IgM isotype and represents a new concept of Aβ-oligomer binders using a combination of high avidity and very low monovalent affinity. This combination creates a selectivity of the antibody towards the oligomeric fraction and minimizes reactivity towards monomeric species.

Reconstitution: For reconstitution add 100 µl of sterile water

Storage: Store lyophilized/reconstituted at 4°C. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

TAIR Nnumbre: N/A

Category: Alzheimer's disease

Research Area: Pathology, Amyloid disorders