AMZ30 | B2714

AMZ30 is a potent, selective, and covalent inhibitor of protein phosphatase methylesterase-1(PME-1; IC50 = 600 nM); selectively inactivates PME-1 and reduces the demethylated form of PP2A in living cells.

AMZ30 is a potent, selective, and covalent inhibitor of protein phosphatase methylesterase-1(PME-1; IC50 = 600 nM); selectively inactivates PME-1 and reduces the demethylated form of PP2A in living cells.

B2714 | AMZ30 DataSheet

Alternate Name/Synonyms: NIH Probe ML136,(E)-2-(4-Fluorophenylsulfonyl)-3-(1-(3-nitrophenylsulfonyl)-1H-pyrrol-2-yl)-acrylonitrile

Appearance: Yellow solid

Formulation:

CAS Number: 1313613-09-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₃FN₃O₆S₂

Molecular Weight: 461.44

Cell-Permeable?: TRUE

Purity: ≥98% HPLC

Solubilities: ~ 4 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A protein phosphatase methylesterase-1(PME-1) inhibitor

MDL Number:

PubChem CID: 44607965

SMILES: C1=CC(=CC(=C1)S(=O)(=O)N2C=CC=C2C=C(C#N)S(=O)(=O)C3=CC=C(C=C3)F)[N+](=O)[O-]

InChi: InChI=1S/C19H12FN3O6S2/c20-14-6-8-17(9-7-14)30(26,27)19(13-21)11-15-4-2-10-22(15)31(28,29)18-5-1-3-16(12-18)23(24)25/h1-12H/b19-11+

InChi Key: GUCUORSUHTZMBW-YBFXNURJSA-N