AN-2728 | B2220

AN-2728 is a boron-based, topical anti-inflammatory agent that acts as a phosphodiesterase 4 (PDE4) inhibitor (IC₅₀ = 0.11 µM). It is less potent against PDE1A, PDE3A, and PDE7A (IC₅₀s = 6.12, 6.41, and 0.73 µM, respectively). AN-2728 suppresses the release of the proinflammatory cytokines TNF-α, IL-2, INF-γ, IL-5, and IL-10 with IC₅₀ values of 0.50, 0.59, 0.72, 2.25, and 2.58 µM, respectively.

AN-2728 is a boron-based, topical anti-inflammatory agent that acts as a phosphodiesterase 4 (PDE4) inhibitor (IC₅₀ = 0.11 µM). It is less potent against PDE1A, PDE3A, and PDE7A (IC₅₀s = 6.12, 6.41, and 0.73 µM, respectively). AN-2728 suppresses the release of the proinflammatory cytokines TNF-α, IL-2, INF-γ, IL-5, and IL-10 with IC₅₀ values of 0.50, 0.59, 0.72, 2.25, and 2.58 µM, respectively.

B2220 | AN-2728 DataSheet

Alternate Name/Synonyms: 4-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)oxy)benzonitrile; Crisaborole

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 906673-24-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₄H₁₀BNO₃

Molecular Weight: 251.04

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent phosphodiesterase 4 (PDE4) inhibitor

MDL Number: MFCD17169940

PubChem CID: 44591583

SMILES: B1(C2=C(CO1)C=C(C=C2)OC3=CC=C(C=C3)C#N)O

InChi: InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2

InChi Key: USZAGAREISWJDP-UHFFFAOYSA-N