Anacetrapib | 2418

Anacetrapib is a potent inhibitor of the cholesteryl ester transfer protein (CETP)-dependent transfer of cholesteryl ester (CE) (IC₅₀ = 17 ± 4.8 nM); it significantly raises HDL cholesterol levels in humans.

Anacetrapib is a potent inhibitor of the cholesteryl ester transfer protein (CETP)-dependent transfer of cholesteryl ester (CE) (IC₅₀ = 17 ± 4.8 nM); it significantly raises HDL cholesterol levels in humans.

2418 | Anacetrapib DataSheet

Alternate Name/Synonyms: (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}methyl)-4-methyl-1,3-oxazolidin-2-one; MK-0859

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 875446-37-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₂₅F₁₀NO₃

Molecular Weight: 637.51

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (>100 mg/ml) or EtOH (>100 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A CETP inhibitor

MDL Number: N/A

PubChem CID: 11556427

SMILES: CC1C(OC(=O)N1CC2=C(C=CC(=C2)C(F)(F)F)C3=CC(=C(C=C3OC)F)C(C)C)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F

InChi: InChI=1S/C30H25F10NO3/c1-14(2)22-11-23(25(43-4)12-24(22)31)21-6-5-18(28InChI=1S/C30H25F10NO3/c1-14(2)22-11-23(25(43-4)12-24(22)31)21-6-5-18(2836)37)10-20(8-16)30(38,39)40/h5-12,14-15,26H,13H2,1-4H3/t15-,26-/m0/s1

InChi Key: MZZLGJHLQGUVPN-HAWMADMCSA-N