Anastrozole | B2177

Anastrozole is a potent aromatase inhibitor that has been shown to effectively eliminate the conversion of androgens to estrogens in peripheral tissues. It inhibits human placental aromatase in vitro with an IC₅₀ value of 15 nM and at doses 100–200 times its maximally effective aromatase inhibitory dose, does not interfere with the biosynthesis of other steroids, including cholesterol, cortisol, and aldosterone

Anastrozole is a potent aromatase inhibitor that has been shown to effectively eliminate the conversion of androgens to estrogens in peripheral tissues. It inhibits human placental aromatase in vitro with an IC₅₀ value of 15 nM and at doses 100–200 times its maximally effective aromatase inhibitory dose, does not interfere with the biosynthesis of other steroids, including cholesterol, cortisol, and aldosterone

B2177 | Anastrozole DataSheet

Alternate Name/Synonyms: α1,α1,α3,α3-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile; ZD1033; Anastrol

Appearance: White solid

Formulation: N/A

CAS Number: 120511-73-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₉N₅

Molecular Weight: 293.4

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent aromatase inhibitor

MDL Number: MFCD00866298

PubChem CID: 2187

SMILES: CC(C)(C#N)C1=CC(=CC(=C1)CN2C=NC=N2)C(C)(C)C#N

InChi: InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3

InChi Key: YBBLVLTVTVSKRW-UHFFFAOYSA-N